Adolfo Garcia-Sastre, Ph.D.

Title: Associate Professor

  • Institution: Mount Sinai School of Medicine
    Phone: (212) 241-7769
    Fax: (212) 534-1684
    Email: [email protected]
  • Mailing Address:
    Mount Sinai School of Medicine
    1 Gustave L Levy Place
    Box 1124
    New York, NY 10029-6500

Lab Web site:

Dr. Garcia-Sastre is analyzing the molecular functions of the NS1 and M1 proteins of the 1918 virus. There is evidence that the NS1 protein of the 1918 virus is an efficient interferon antagonist in human cells but not in mouse cells, and Dr. Garcia-Sastre is characterizing the molecular determinants responsible for this specificity. In addition, the antiviral properties and the regulation of previously uncharacterized cellular proteins whose expression is inhibited by the NS1 protein of 1918 virus are being investigated. These studies also serve to validate microarray experiments (conducted by Dr. Katze) aimed at investigating the role of the NS1 protein in regulating host gene expression. Finally, Dr. Garcia-Sastre's lab has demonstrated that the M1 protein of influenza virus determines the morphology (spherical or filamentous) of influenza viruses. Since virus particle shape may influence the ability of the virus to spread, the role of the M1 protein of 1918 virus in viral morphology is being investigated.

News from Mt. Sinai School of Medicine

Technique developed and patented by Mount Sinai School of Medicine researchers used to reconstruct 1918 virus.