Michael G. Katze, Ph.D.

Title: Professor of Microbiology

  • Institution: University of Washington
    Phone: (206) 732-6135
    Fax: (206) 732-6056
    Email: [email protected]
  • Mailing Address:
    Department of Microbiology
    University of Washington
    Box 358070
    Seattle, WA 98195-8070

Lab Web site: #

Dr. Katze's lab provides a macaque model of influenza virus infection and performs global gene expression profiling of the cellular response to influenza virus infection. A nonhuman primate model of influenza virus allows investigators to compare the clinical course, pathology, and gene expression patterns in several tissues of macaques following challenge with influenza virus. The availability of a nonhuman primate model of influenza virus provides an important resource for studying the pathogenesis of this virus as well as therapeutic and vaccine strategies. Studies using recombinant viruses in macaques are conducted under high containment conditions. In the second objective, the laboratory is using DNA microarrays to profile changes in cellular gene expression in response to wild type and recombinant strains of influenza virus. The goal is to analyze the effects of specific viral gene products associated with the 1918 pandemic strain on cellular gene expression and to attempt to elucidate the mechanisms by which certain strains of influenza virus become highly pathogenic. Analyses are performed using human or mouse cells infected in vitro, and with tissues isolated from infected mice and macaques. Gene expression studies using macaque tissues are be performed using macaque DNA arrays that have been constructed in the Katze laboratory.

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