Genomic and proteomic data can be accessed by following the links provided in the Data column on this page or through the Katze Lab Informatics Server.

For questions about or assistance with data access, please contact: [email protected].

Authors Title Citation Data
Ahmed, R., M. B. A. Oldstone, and P. Palese Protective immunity and susceptibility to infectious diseases: lessons from the 1918 influenza pandemic Nature Immunol. 8:1188-1193  
Baskin, C.R., H. Bielefeldt-Ohmann, A. Garcia-Sastre, T.M. Tumpey, N. Van Hoeven, V.S. Carter, M.J. Thomas, S. Proll, A. Solorzano, R. Billharz, J.L. Fornek, S. Thomas, C.H. Chen, E.A. Clark, M.K. Kaja, and M.G. Katze Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus J. Virol. 81:11817-11827 Informatics Server
Conenello, G. M., D. Zamarin, L. A. Perrone, T. Tumpey, and P. Palese A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence PLoS Pathog. 3:e141  
Glaser, L., G. Conenello, J. Paulson, and P. Palese Effective replication of human influenza viruses in mice lacking a major alpha 2,6 sialyltransferase Virus Res. 126:9-18  
Grimm, D., P. Staeheli, M. Hufbauer, I. Koerner, L. Martinez- Sobrido, A. Solorzano, A. Garcia-Sastre, O. Haller, and G. Kochs Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene Proc. Natl. Acad. Sci. USA 104:6806-6811  
Kochs, G., A. Garcia-Sastre, and L. Martinez-Sobrido Multiple anti-interferon actions of the influenza A virus NS1 protein J. Virol. 81:7011-7021  
Lenschow, D. J., C. Lai, N. Frias-Staheli, N. V. Giannakopoulos, A. Lutz, T. Wolff, A. Osiak, B. Levine, R. E. Schmidt, A. Garcia-Sastre, D. A. Leib, A. Pekosz, K.-P. Knobeloch, I. Horak, and H. W. Virgin IV IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes and Sindbis viruses Proc. Natl. Acad. Sci. USA 104:1371-1376  
Taubenberger, J. K., J. Hultin, and D. Morens Discovery and characterization of the 1918 pandemic influenza virus in historical context Antiviral Therapy 12:581-591  
Taubenberger, J. K., D. Morens, and A. S. Fauci The next influenza pandemic: can it be predicted? JAMA 297:2025-2027  
Ten Oever, B. R., S.-L. Ng, M. A. Chua, S. M. McWhirter, A. Garcia-Sastre, and T. Maniatis Multiple functions of the IKK-related kinase IKKepsilon in interferon-mediated antiviral immunity Science 315:1274-1278  
Tumpey, T. M., T. R. Maines, N. van Hoeven, L. Glaser, A. Solorzano, C. Pappas, N. J. Cox, D. E. Swayne, P. Palese, J. M. Katz, and A. Garcia-Sastre A two-amino acid change in the hemagglutinin of the 1918 influenza virus abolishes transmission Science 315:655-659  
Tumpey, T. M., K. J. Szretter, N. Van Hoeven, J. M. Katz, G. Kochs, O. Haller, A. Garcia-Sastre, and P. Staeheli The Mx1 gene protects mice against the pandemic 1918 and highly lethal H5N1 influenza viruses J. Virol. 81:10818-10821  
2006 TOP
Baas, T., C. R. Baskin, D. L. Diamond, A. Garcia-Sastre, H. Bielefeldt-Ohmann, T. M. Tumpey, M. J. Thomas, V. S. Carter, T. H. Teal, N. Van Hoeven, S. C. Proll, J. M. Jacobs, Z. R. Caldwell, M. A. Gritsenko, R. R. Hukkanen, D. G. Camp, R. D. Smith, and M. G. Katze An integrated molecular signature of disease: analysis of influenza virus-infected macaques through functional genomics and proteomics J. Virol. 80:10813-10828 Informatics Server

NCRR Proteomics
Garcia-Sastre, A. and C. A. Biron Type 1 interferons and the virus-host relationship: a lesson in detente Science 312:879-882  
Garcia-Sastre, A. and R. Whitley Lessons learned from reconstructing the 1918 influenza virus pandemic J. Infect. Dis. 94: S127-S132  
Glaser, L., G. Conenello, J. Paulson, and P. Palese Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice J. Virol. 80:7976-7983  
Kash, J. C., T. M. Tumpey, S. C. Proll, V. Carter, O. Perwitasari, M. J. Thomas, C. F. Basler, P. Palese, J. K. Taubenberger, A. Garcia-Sastre, D. E. Swayne, and M. G. Katze Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus Nature 443:578-581 Informatics Server
Kong, W., P., C. Hood, Z. Y. Yang, C. J. Wei, L. Xu, A. Garcia-Sastre, T. M. Tumpey, and G. J. Nabel Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination Proc. Natl. Acad. Sci. USA 103:15987-15991  
Palese, P. Making better influenza virus vaccines? J. Infect. Dis. 12:61-65  
Palese, P., T. M. Tumpey, and A. Garcia-Sastre What can we learn from reconstructing the extinct 1918 pandemic influenza virus? Immunity 24:121-124  
Stevens, J., O. Blixt, J. C. Paulson, and I. A. Wilson Glycan microarray technologies: tools to survey host specificity of influenza viruses Nature Rev. Microbiol. 4:857-864  
Stevens, J., O. Blixt, T. M. Tumpey, J. K. Taubenberger, J. C. Paulson, and I. A. Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus Science 312:404-410, Wilson  
Taubenberger, J. K. The origin and virulence of the 1918 "Spanish" influenza virus Proc. Am. Philos. Soc. 150:86-112  
Taubenberger, J. K. and D. Morens 1918 Influenza: the mother of all pandemics Emerg. Infect. Dis. 12:15-22  
2005 TOP
Bourmakina, S. V. and A. Garcia-Sastre The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells J. Virol. 79:7926-7932  
Glaser, L, J. Stevens, D. Zamarin, I. A. Wilson, A. Garcia-Sastre, T. M. Tumpey, C. F. Basler, J. K. Taubenberger, and P. Palese A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity J. Virol. 79:11533:11546  
Tumpey, T. M., C. F. Basler, P. V. Aguilar, H. Zeng, A. Solorzano, D. E. Swayne, N. J. Cox, J. M. Katz, J. K. Taubenberger, P. Palese, and A. Garcia-Sastre Characterization of the reconstructed 1918 Spanish influenza pandemic virus Science 310:77-80  
Tumpey, T. M., A. Garcia-Sastre, J. K. Taubenberger, P. Palese, D. E. Swayne, M. J. Pantin-Jackwood, S. Schultz-Cherry, A. Solorzano, N. Van Rooijen, J. M. Katz, and C. F. Basler Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice J. Virol. 79:14933-14944  
2004 TOP
Baskin, C. R., A. Garcia-Sastre, T. M. Tumpey, H. Bielefeldt-Ohmann, V. S. Carter, E. Nistal-Villan, and M. G. Katze Integration of clinical data, pathology, and cDNA microarrays in influenza virus-infected pigtailed macaques (Macaca nemestrina). J. Virol. 78:10420-10432 Informatics Server
Kash J.C., C.F. Basler, A. Garcia-Sastre, V. Carter, R. Billharz, D.E. Swayne, R.M. Przygodzki, J.K. Taubenberger, M.G. Katze, and T.M. Tumpey Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus J. Virol. 78:9499-9511 Informatics Server
Palese, P. Influenza: old and new threats Nature Med. 10:S82-S87  
Stevens J., A. L. Corper, C. F. Basler, J. K., Taubenberger, P. Palese, and I. A. Wilson Structure of uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus Science 303:1866-1870  
Tumpey T. M., A. Garcia-Sastre, J. K., Taubenberger, P. Palese, D. E. Swayne, and C. F. Basler Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus Proc. Natl. Acad. Sci. USA 101:3166-3171