Title: Professor, Department of Molecular Biology

  • Institution: The Scripps Research Institute
    Phone: (858) 784-9706
    Fax: (858) 784-2980
    Email: [email protected]
  • Mailing Address:
    The Scripps Research Institute
    Department of Molecular Biology
    10550 North Torrey Pines Rd.
    La Jolla, CA 92037-1000

Lab Web site: http://www.scripps.edu/mb/wilson/

Dr. Wilson studies the structure of the main antigens of the virus, HA and NA, as well as the NS1 protein, an important virulence factor that is required for efficient viral evasion of host innate immunity. Dr. Wilson's project is based on the sequence of the HA (H1), NA (N1) and NS1 proteins of the 1918 virus, as previously determined by Dr. Taubenberger. Using novel ways to express these proteins in insect cells, Dr. Wilson's laboratory has been able to express and purify trimers of the ectodomain of 1918 HA protein at a quality level sufficient to result in crystallization. Solving the crystallographic structure of the 1918 HA, NA and NS1 proteins is required to understand the structure-function relationship responsible for the antigenicity and potential virulence associated with critical domains in these proteins identified by Program investigators.

News from The Scripps Research Institute:

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